Research Article
Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-dione
D. GILES*, M. S. PRAKASH, and K. V. RAMSESHU
ABSTRACT
Indane-1, 3-dione (1) synthesized by condensation of diethyl phthalate and ethyl acetate in presence of sodium ethoxide gave sodium salt of ester derivative, which on neutralization in presence of sulphuric acid afford 1. Various thiols where converted to their respective disulphide (3) which on treatment with 1 gave 2-substituted thio phenyl derivatives (4a-g) of 1. The synthesized compounds were characterized on the basis of IR and H1NMR. Synthesized compounds (4a-g) were investigated for their anticoagulant, analgesic, anti-inflammatory, antifungal, antibacterial and anticancer activities. Some of the synthesized compounds have shown moderate activities.
Received 18 January 2007; Accepted 2 March 2007