E-Journal of Chemistry

Research Article

E-J.Chem , Volume 4, Number 3, p 376-380

Synthesis and Characterization of 6-Carbamoyl-1,2-dihydropurines

Department of Chemistry, University of Guilan, P.O. Box 1914, Rasht, Iran.

ABSTRACT

The aromatic amines react readily with (Z)-N-(2-amino-1,2- dicyanovinyl)formimidate (4) to give the amidines (5a-b), which cyclize in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) to give the corresponding 2-(5-Amino-1-phenyl-1H-imidazol-4-yl)-2-iminoacetonitrile (6a-b), which can be isolated. In the presence of aldehyde the formimidoylimidazole lead to novel 6-carbamoyl-1,2-dihydropurines (8a-b). All compounds have been fully characterized by spectroscopic data.

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