E-Journal of Chemistry

Review Article

E-J.Chem , Volume 4, Number 3, p 294-301

Nuclear Magnetic Resonance Spectroscopy an Evolutionary Approach to Drug Design

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University,
Sagar 470 003, M.P., India.
^#Institute of Pharmacy, Pt. Ravi Shankar Shukla University,Raipur, Chhattisgarh
^†G.L.A. Institute of Pharmaceutical Research, Mathura, U.P., India.

ABSTRACT

Ever since Nuclear Magnetic Resonance (NMR) spectroscopy hit the analytical scene; its capabilities and applications continue to evolve. Originally designed as a way to verify the structure of relatively small compounds, the technology of NMR has exploded and become a valuable means for studying protein structure. NMR has proved to be a valuable tool in pharmaceutical research, as it has entered new arena of drug discovery and structural genomics. NMR can provide information on the three-dimensional structures of small molecules in solution, high-molecular-weight complexes, and the details of enzyme mechanisms that can be used to aid in drug design. In the present scenario, the availability of high magnetic fields; improved software, high resolution probes, and electronics; more versatile pulse programmers; and most importantly the development of 2D, 3D and 4D NMR, have revolutionized the field of drug discovery and development.

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